Buonomano D V, Cleary L J, Byrne J H
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77225.
Brain Res. 1992 Apr 10;577(1):147-50. doi: 10.1016/0006-8993(92)90548-n.
We have identified an inhibitory neuron (RPL4) in the right pleural ganglion of Aplysia, which produced hyperpolarization of the sensory and motor neurons involved in the tail withdrawal reflex. Activation of RPL4 significantly reduced the amplitude of excitatory postsynaptic potentials produced in tail motor neurons by action potentials triggered in sensory neurons. This example of heterosynaptic inhibition was due, at least in part, to an increase in membrane input conductance in the motor neuron. Since the synaptic strength of the sensory-to-motor neuron connection has been associated with the strength of the tail withdrawal reflex, RPL4 may contribute to modulation of that reflex.
我们在海兔的右侧胸膜神经节中鉴定出一种抑制性神经元（RPL4），它能使参与缩尾反射的感觉神经元和运动神经元发生超极化。激活RPL4可显著降低感觉神经元触发的动作电位在尾部运动神经元中产生的兴奋性突触后电位的幅度。这种异突触抑制的例子至少部分是由于运动神经元膜输入电导的增加。由于感觉神经元与运动神经元连接的突触强度与缩尾反射的强度相关，RPL4可能有助于对该反射的调节。
