Framson Paul E, Sage E Helene
Department of Vascular Biology, The Hope Heart Institute, 1124 Columbia Street, Seattle, Washington 98104, USA.
J Cell Biochem. 2004 Jul 1;92(4):679-90. doi: 10.1002/jcb.20091.
Matricellular proteins mediate interactions between cells and their extracellular environment. This functional protein family includes several structurally unrelated members, such as SPARC, thrombospondin 1, tenascin C, and osteopontin, as well as some homologs of these proteins, such as thrombospondin 2 and tensascin X. SPARC, a prototypic matricellular protein, and its homolog hevin, have deadhesive effects on cultured cells and have been characterized as antiproliferative factors in some cellular contexts. Both proteins are produced at high levels in many types of cancers, especially by cells associated with tumor stroma and vasculature. In this Prospect article we summarize evidence for SPARC and hevin in the regulation of tumor cell growth, differentiation, and metastasis, and we propose that matricellular proteins such as these perform critical functions in desmoplastic responses of tumors that culminate in their dissemination and eventual colonization of other sites.
基质细胞蛋白介导细胞与其细胞外环境之间的相互作用。这个功能性蛋白家族包括几个结构不相关的成员，如富含半胱氨酸的酸性分泌蛋白（SPARC）、血小板反应蛋白1、腱生蛋白C和骨桥蛋白，以及这些蛋白的一些同源物，如血小板反应蛋白2和腱生蛋白X。SPARC作为一种典型的基质细胞蛋白及其同源物纽蛋白，对培养细胞具有去黏附作用，并且在某些细胞环境中被表征为抗增殖因子。这两种蛋白在许多类型的癌症中都高水平表达，尤其是由与肿瘤基质和脉管系统相关的细胞产生。在这篇展望文章中，我们总结了SPARC和纽蛋白在调节肿瘤细胞生长、分化和转移方面的证据，并且我们提出像这样的基质细胞蛋白在肿瘤的促结缔组织增生反应中发挥关键作用，最终导致肿瘤的播散及其在其他部位的最终定植。
