Crépel V, Krnjević K, Ben-Ari Y
Anaesthesia Research Department, McGill University, Montréal, Québec, Canada.
Can J Physiol Pharmacol. 1992 Feb;70(2):306-7. doi: 10.1139/y92-038.
Sulphonylurea drugs, such as glibenclamide and tolbutamide, are widely used as selective blockers of adenosine triphosphate-sensitive K channels. In experiments on hippocampal slices (from Wistar rats) glibenclamide (and possibly gliquidone and tolbutamide) significantly reduced the highly voltage-dependent, 4-aminopyridine-sensitive D-type outward current of CA3 neurons. Judging by these observations, the sulphonylureas may not be as selective as generally believed.
磺酰脲类药物，如格列本脲和甲苯磺丁脲，被广泛用作三磷酸腺苷敏感性钾通道的选择性阻滞剂。在对（来自Wistar大鼠的）海马切片进行的实验中，格列本脲（可能还有格列喹酮和甲苯磺丁脲）显著降低了CA3神经元高度电压依赖性、对4-氨基吡啶敏感的D型外向电流。从这些观察结果来看，磺酰脲类药物可能并不像人们普遍认为的那样具有选择性。
