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Circulating immunoglobulins that inhibit the binding of follicle-stimulating hormone to its receptor: a putative diagnostic role in resistant ovary syndrome?

作者信息

Chiauzzi Violeta A, Bussmann Leonardo, Calvo Juan Carlos, Sundblad Victoria, Charreau Eduardo H

机构信息

Instituto de Biología y Medicina Experimental (IBYME), Buenos Aires, Argentina.

出版信息

Clin Endocrinol (Oxf). 2004 Jul;61(1):46-54. doi: 10.1111/j.1365-2265.2004.02054.x.

DOI:10.1111/j.1365-2265.2004.02054.x
PMID:15212644
Abstract

OBJECTIVE

To evaluate the presence of circulating immunoglobulins that inhibit FSH binding to its receptor (Ig-FSHR) in patients with premature ovarian failure (POF).

DESIGN

Non-randomized study. Blood sampling for determination of circulating immunoglobulins. patients Two hundred and forty-seven patients with POF and 60 normally menstruating women (controls). measurements Circulating immunoglobulins that inhibit FSH binding to its receptor were assessed by FSH-binding inhibition assay.

RESULTS

Twenty-three out of 247 women with POF presented circulating immunoglobulins that inhibit FSH binding to its receptor. These patients had been previously diagnosed as ROS. Sixty control subjects proved negative.

CONCLUSION

Determination of the presence of circulating immunoglobulins that inhibit FSH binding to its receptor could be instrumental in diagnosing the gonadotropin resistance ovary syndrome.

摘要

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