Loeffler David A, Camp Dianne M, Schonberger Michael B, Singer Daniel J, LeWitt Peter A
Division of Neurology, William Beaumont Hospital Research Institute, Royal Oak, MI 48073, USA.
Neurobiol Aging. 2004 Sep;25(8):1001-7. doi: 10.1016/j.neurobiolaging.2003.11.003.
Complement activation is increased in Alzheimer's disease (AD) and may contribute to the development and progression of this disorder. To compare early complement activation between normal and AD brain specimens, C4d and iC3b concentrations were measured in hippocampus, entorhinal cortex, temporal cortex, parietal cortex, and cerebellum from aged normal and AD subjects n=10-14 for both), and in hippocampus and entorhinal cortex from younger normal subjects (n=5-6). C4d and iC3b levels increased 2.3- to 4.6-fold in AD versus aged normal specimens (all P <0.05), with lowest concentrations of these activation proteins generally in cerebellum. No significant differences were present between aged and younger normal C4d and iC3b levels in hippocampus or entorhinal cortex. However, the concentrations of these proteins were markedly increased in several aged normal specimens. Normal subject age was moderately associated with both C4d (r=0.49) and iC3b (r=0.53) concentrations in the hippocampus. Increased brain complement activation in some elderly individuals may promote the subsequent development of AD.
阿尔茨海默病（AD）中补体激活增加，可能促使该疾病的发生和发展。为比较正常脑标本与AD脑标本的早期补体激活情况，对老年正常受试者和AD受试者（两组均为n = 10 - 14）的海马体、内嗅皮质、颞叶皮质、顶叶皮质及小脑，以及年轻正常受试者（n = 5 - 6）的海马体和内嗅皮质中的C4d和iC3b浓度进行了测量。与老年正常标本相比，AD标本中的C4d和iC3b水平升高了2.3至4.6倍（所有P < 0.05），这些激活蛋白的浓度通常在小脑中最低。在海马体或内嗅皮质中，老年正常受试者与年轻正常受试者的C4d和iC3b水平无显著差异。然而，在一些老年正常标本中，这些蛋白的浓度显著升高。正常受试者的年龄与海马体中C4d（r = 0.49）和iC3b（r = 0.53）的浓度呈中度相关。一些老年人脑内补体激活增加可能会促使随后AD的发生。
