Abdul Shajahan, Poddar S S
Department of Pharmaceutics, Principal K.M. Kundnani College of Pharmacy, Plot No. 47, R.G.Thadani Marg, Worliseafce, Mumbai-400018, India.
J Control Release. 2004 Jul 7;97(3):393-405. doi: 10.1016/j.jconrel.2004.03.034.
Modified release dosage forms offer definite advantages over conventional release formulation of the same drug. Hydrophilic polymers are mainly used for preparation of matrix type controlled delivery systems. The system usually provides nonlinear release profile. The multi-layered matrix system overcomes inherent disadvantages of non-linearity associated with diffusion controlled matrix devices by providing additional release surface with time to compensate for the decreasing release rate. This technology also demonstrates a wide flexibility for various applications. In this article, we review system design, various constructions and formulation parameters of modified release dosage forms.
缓释剂型相对于相同药物的常规释放制剂具有明显优势。亲水性聚合物主要用于制备基质型控释系统。该系统通常呈现非线性释放曲线。多层基质系统通过随时间提供额外的释放表面来补偿释放速率的降低，克服了与扩散控制基质装置相关的非线性固有缺点。该技术在各种应用中也展现出广泛的灵活性。在本文中，我们综述了缓释剂型的系统设计、各种结构和制剂参数。
