Hopkins Eileen, Rossi Grace, Kest Benjamin
Neuropsychology Doctoral Subprogram, Queens College, City University of New York, Flushing, NY 11367, USA.
Brain Res. 2004 Jul 16;1014(1-2):244-6. doi: 10.1016/j.brainres.2004.03.056.
Morphine analgesic potency following systemic administration was assessed in male and female mice undergoing prior and repeated intrathecal morphine injections. Although morphine ED50 values were significantly increased in both sexes relative to their respective saline-injected controls, the magnitude of tolerance was greater in females. Intrathecal injection alone had no effect on morphine analgesia. The data suggest that spinal mechanisms contribute to sex differences in analgesic tolerance following systemic morphine administration.
在接受过鞘内注射吗啡且多次重复注射的雄性和雌性小鼠中，评估了全身给药后吗啡的镇痛效力。尽管相对于各自注射生理盐水的对照组，两性的吗啡半数有效剂量（ED50）值均显著增加，但雌性的耐受程度更高。单独鞘内注射对吗啡镇痛无影响。这些数据表明，脊髓机制导致了全身注射吗啡后镇痛耐受性的性别差异。
