Sayer Avan Aihie, Syddall Holly E, Dennison Elaine M, Gilbody Helen J, Duggleby Sarah L, Cooper Cyrus, Barker David J, Phillips David I
Medical Research Council Environmental Epidemiology Unit, University of Southampton, Southamption, United Kingdom.
Am J Clin Nutr. 2004 Jul;80(1):199-203. doi: 10.1093/ajcn/80.1.199.
Size in early life is related to adult body mass index, and early environmental influences have been proposed to have lifelong consequences for obesity. However, body mass index also reflects fat-free mass, and few studies have examined the relation between size in early life and direct measures of body composition in older people.
We investigated the associations of birth weight and weight at 1 y of age with body composition in older men.
We carried out a retrospective cohort study in Hertfordshire, United Kingdom. Men who were born between 1931 and 1939 and for whom there were records of birth weight and weight at 1 y of age (n = 737) participated in the study. The main outcome measures were adult body mass index, fat-free mass, and fat mass.
Birth weight was significantly and consistently positively associated with adult body mass index and fat-free mass but not with measures of adult fat mass. In contrast, weight at 1 y of age was associated with adult body mass index, fat-free mass, and fat mass.
The consistently reported positive relation between birth weight and adult body mass index may reflect prenatal and maternal influences on fat-free mass rather than on fat mass in older people. The postnatal environment may be more influential than prenatal factors in the development of obesity in later life.
生命早期的体型与成人身体质量指数相关，并且有人提出早期环境影响对肥胖具有终身影响。然而，身体质量指数也反映了去脂体重，很少有研究探讨生命早期的体型与老年人身体成分直接测量指标之间的关系。
我们研究了老年男性出生体重和1岁时体重与身体成分之间的关联。
我们在英国赫特福德郡进行了一项回顾性队列研究。1931年至1939年出生且有出生体重和1岁时体重记录的男性（n = 737）参与了该研究。主要结局指标为成人身体质量指数、去脂体重和脂肪量。
出生体重与成人身体质量指数和去脂体重显著且持续正相关，但与成人脂肪量指标无关。相比之下，1岁时体重与成人身体质量指数、去脂体重和脂肪量均相关。
出生体重与成人身体质量指数之间持续报道的正相关关系可能反映了产前和母体对老年人去脂体重而非脂肪量的影响。产后环境在晚年肥胖发展中可能比产前因素更具影响力。
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