Department of Population and Family Health, Faculty of Public Health, Department of Pediatrics and Child Health, Faculty of Medical Sciences.
Department of Nutrition, Exercise, and Sports, University of Copenhagen, Copenhagen, Denmark.
J Nutr. 2018 Apr 1;148(4):607-615. doi: 10.1093/jn/nxy003.
We have previously shown that fat-free mass (FFM) at birth is associated with height at 2 y of age in Ethiopian children. However, to our knowledge, the relation between changes in body composition during early infancy and later linear growth has not been studied.
This study examined the associations of early infancy fat mass (FM) and FFM accretion with linear growth from 1 to 5 y of age in Ethiopian children.
In the infant Anthropometry and Body Composition (iABC) study, a prospective cohort study was carried out in children in Jimma, Ethiopia, followed from birth to 5 y of age. FM and FFM were measured ≤6 times from birth to 6 mo by using air-displacement plethysmography. Linear mixed-effects models were used to identify associations between standardized FM and FFM accretion rates during early infancy and linear growth from 1 to 5 y of age. Standardized accretion rates were obtained by dividing FM and FFM accretion by their respective SD.
FFM accretion from 0 to 6 mo of age was positively associated with length at 1 y (β = 0.64; 95% CI: 0.19, 1.09; P = 0.005) and linear growth from 1 to 5 y (β = 0.63; 95% CI: 0.19, 1.07; P = 0.005). The strongest association with FFM accretion was observed at 1 y. The association with linear growth from 1 to 5 y was mainly engendered by the 1-y association. FM accretion from 0 to 4 mo was positively associated with linear growth from 1 to 5 y (β = 0.45; 95% CI: 0.02, 0.88; P = 0.038) in the fully adjusted model.
In Ethiopian children, FFM accretion was associated with linear growth at 1 y and no clear additional longitudinal effect from 1 to 5 y was observed. FM accretion showed a weak association from 1 to 5 y. This trial was registered at www.controlled-trials.com as ISRCTN46718296.
我们之前的研究表明，埃塞俄比亚儿童出生时的无脂肪质量（FFM）与 2 岁时的身高相关。然而，据我们所知，婴儿期身体成分的变化与之后线性生长的关系尚未被研究。
本研究旨在探讨婴儿期脂肪质量（FM）和 FFM 积累与埃塞俄比亚儿童从 1 岁到 5 岁的线性生长之间的关联。
在婴儿人体测量学和身体成分（iABC）研究中，我们在埃塞俄比亚的吉马进行了一项前瞻性队列研究，对儿童从出生到 5 岁进行了随访。FM 和 FFM 采用空气置换体积描记法在出生后 6 个月内测量了≤6 次。使用线性混合效应模型来确定婴儿期早期 FM 和 FFM 积累率与从 1 岁到 5 岁的线性生长之间的关联。通过将 FM 和 FFM 积累除以各自的标准差来获得标准化的积累率。
0 至 6 个月的 FFM 积累与 1 岁时的身高呈正相关（β=0.64；95%CI：0.19，1.09；P=0.005），与从 1 岁到 5 岁的线性生长呈正相关（β=0.63；95%CI：0.19，1.07；P=0.005）。与 FFM 积累的最强关联发生在 1 岁时。与从 1 岁到 5 岁的线性生长的关联主要是由 1 岁时的关联引起的。0 至 4 个月的 FM 积累与完全调整后的模型中从 1 岁到 5 岁的线性生长呈正相关（β=0.45；95%CI：0.02，0.88；P=0.038）。
在埃塞俄比亚儿童中，FFM 积累与 1 岁时的线性生长相关，从 1 岁到 5 岁没有观察到明显的纵向影响。FM 积累与从 1 岁到 5 岁的线性生长呈弱相关。该试验在 www.controlled-trials.com 上注册，编号为 ISRCTN46718296。
