铜绿假单胞菌的绿脓菌素对小鼠肺部感染至关重要。
Pseudomonas aeruginosa pyocyanin is critical for lung infection in mice.
作者信息
Lau Gee W, Ran Huimin, Kong Fansheng, Hassett Daniel J, Mavrodi Dimitri
机构信息
Division of Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, 231 Albert Sabin Way, MSB 6006, Cincinnati, OH 45267-0564, USA.
出版信息
Infect Immun. 2004 Jul;72(7):4275-8. doi: 10.1128/IAI.72.7.4275-4278.2004.
Abstract
Pseudomonas aeruginosa secretes copious amounts of the redox-active phenazine, pyocyanin (PCN), during cystic fibrosis lung infection. PCN has been shown to interfere with a variety of cellular processes in cultured lung epithelial cells. Here, by using two respiratory tract models of infection, we demonstrate that PCN mediates tissue damage and necrosis during lung infection.
摘要
在囊性纤维化肺部感染期间，铜绿假单胞菌会分泌大量具有氧化还原活性的吩嗪——绿脓菌素（PCN）。研究表明，PCN会干扰培养的肺上皮细胞中的多种细胞过程。在此，我们通过使用两种呼吸道感染模型证明，PCN在肺部感染期间会介导组织损伤和坏死。
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