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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Gordon R D, Ballantine D M, Bachmann A W

University of Queensland Department of Medicine, Greenslopes Hospital, Brisbane, Australia.

Clin Exp Pharmacol Physiol. 1992 May;19(5):287-90. doi: 10.1111/j.1440-1681.1992.tb00453.x.

Increases in blood pressure (BP) and in plasma noradrenaline concentration (NA) were observed after two doses of a non-prescription decongestant containing pseudoephedrine (PE) in two of three patients with phaeochromocytoma, before but not after removal of the tumour. The pressor response was terminated by oral phenoxybenzamine, and modified by prior exposure to this drug. 2. In eight normal subjects administration of the same two doses prevented falls in BP and in NA usually seen with prolonged recumbency, but neither BP nor NA increased. However, a pressor response was observed in a normal subject with a strong family history of hypertension. 3. Exposure to PE in non-prescription decongestants is not without risk in hypertension.

在3例嗜铬细胞瘤患者中，有2例在切除肿瘤前给予两剂含伪麻黄碱（PE）的非处方减充血剂后，观察到血压（BP）和血浆去甲肾上腺素浓度（NA）升高，而切除肿瘤后则未出现这种情况。升压反应可通过口服酚苄明终止，并可因事先使用该药而减轻。2. 在8名正常受试者中，给予相同的两剂药物可防止通常因长时间卧床而出现的BP和NA下降，但BP和NA均未升高。然而，在一名有强烈高血压家族史的正常受试者中观察到了升压反应。3. 非处方减充血剂中的PE暴露在高血压患者中并非没有风险。

Gordon R D, Ballantine D M, Bachmann A W

University of Queensland Department of Medicine, Greenslopes Hospital, Brisbane, Australia.

Clin Exp Pharmacol Physiol. 1992 May;19(5):287-90. doi: 10.1111/j.1440-1681.1992.tb00453.x.

Increases in blood pressure (BP) and in plasma noradrenaline concentration (NA) were observed after two doses of a non-prescription decongestant containing pseudoephedrine (PE) in two of three patients with phaeochromocytoma, before but not after removal of the tumour. The pressor response was terminated by oral phenoxybenzamine, and modified by prior exposure to this drug. 2. In eight normal subjects administration of the same two doses prevented falls in BP and in NA usually seen with prolonged recumbency, but neither BP nor NA increased. However, a pressor response was observed in a normal subject with a strong family history of hypertension. 3. Exposure to PE in non-prescription decongestants is not without risk in hypertension.

在3例嗜铬细胞瘤患者中，有2例在切除肿瘤前给予两剂含伪麻黄碱（PE）的非处方减充血剂后，观察到血压（BP）和血浆去甲肾上腺素浓度（NA）升高，而切除肿瘤后则未出现这种情况。升压反应可通过口服酚苄明终止，并可因事先使用该药而减轻。2. 在8名正常受试者中，给予相同的两剂药物可防止通常因长时间卧床而出现的BP和NA下降，但BP和NA均未升高。然而，在一名有强烈高血压家族史的正常受试者中观察到了升压反应。3. 非处方减充血剂中的PE暴露在高血压患者中并非没有风险。