检测甲状腺乳头状癌和滤泡状癌随访中的循环Tg-mRNA：其作用有多大？
Detection of circulating Tg-mRNA in the follow-up of papillary and follicular thyroid cancer: how useful is it?
作者信息
Verburg F A, Lips C J M, Lentjes E G W M, de Klerk J M H
机构信息
Department of Nuclear Medicine, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands.
出版信息
Br J Cancer. 2004 Jul 19;91(2):200-4. doi: 10.1038/sj.bjc.6601991.
Abstract
To investigate the usefulness of thyroglobulin mRNA (Tg-mRNA) detection in peripheral blood in the follow-up of papillary and follicular (differentiated) thyroid cancer, a literature study was performed. Both evidence for and evidence against the usefulness of Tg-mRNA detection were found. Also, evidence for the expression of Tg-mRNA in cells other than normal or neoplastic thyroid follicular cells was found. It is concluded that currently Tg-mRNA detection is not a useful tool in the follow-up of differentiated thyroid carcinoma, but that the concept of using RT-PCR measurements during follow-up still warrants further research.
摘要
为研究甲状腺球蛋白mRNA（Tg-mRNA）检测在乳头状和滤泡状（分化型）甲状腺癌随访中在外周血中的应用价值，进行了一项文献研究。发现了支持和反对Tg-mRNA检测有用性的证据。此外，还发现了除正常或肿瘤性甲状腺滤泡细胞外的细胞中Tg-mRNA表达的证据。结论是，目前Tg-mRNA检测在分化型甲状腺癌随访中不是一个有用的工具，但在随访期间使用逆转录聚合酶链反应测量的概念仍值得进一步研究。
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