Linkage analysis and predicting genetic disease.
作者信息
Boughman J A, Stick M J, Peterson D A, Cohen M M
机构信息
Department of Obstetrics and Gynecology, University of Maryland School of Medicine, Baltimore.
出版信息
Clin Lab Med. 1992 Sep;12(3):449-61.
PMID:1521423
Abstract
Linkage analysis is an important and clinically applicable method of predicting risk for genetic disorders and traits. When a gene cannot be detected directly, evaluation of a closely linked marker may be used in risk assessment. This review of linkage analysis provides basic information and examples of the application of these methods in genetic counseling situations.
摘要
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