Lejon Tore, Stiberg Trine, Strøm Morten B, Svendsen John S
Department of Chemistry, University of Tromsø, N-9037 Tromsø, Norway.
J Pept Sci. 2004 Jun;10(6):329-35. doi: 10.1002/psc.553.
The antibacterial activity against Escherichia coli and Staphylococcus aureus has been studied for a number of modified pentadecapeptides based on lactoferricins of different origin. The peptides were classified by multivariate methods and quantitative structure-activity relationships (QSAR) were developed using theoretically derived variables for the amino acids. For the modified peptides based on bovine lactoferricin (LFB) a model was calculated and used for prediction of new peptides that were then tested for antibacterial activity in order to improve peptide activity and to check the validity of the model. Models were also calculated including lactoferricins of different origin. Theories of the mechanism of action of the peptides are briefly discussed.
针对多种基于不同来源乳铁传递蛋白的修饰十五肽，研究了其对大肠杆菌和金黄色葡萄球菌的抗菌活性。通过多变量方法对这些肽进行分类，并利用氨基酸的理论衍生变量建立了定量构效关系（QSAR）。对于基于牛乳铁传递蛋白（LFB）的修饰肽，计算了一个模型并用于预测新的肽，然后对这些新肽进行抗菌活性测试，以提高肽的活性并检验模型的有效性。还计算了包含不同来源乳铁传递蛋白的模型。简要讨论了肽的作用机制理论。
