果糖-1,6-二磷酸不能改善新生猪中枢神经系统的缺氧缺血性损伤。
Fructose-1,6-bisphosphate does not ameliorate hypoxic ischemic injury to the central nervous system in the newborn pig.
作者信息
LeBlanc M H, Parker C C, Vig V, Smith E E, Brown E G
机构信息
Department of Pediatrics, University of Mississippi Medical Center, Jackson 39216-4505.
出版信息
Crit Care Med. 1992 Sep;20(9):1309-14. doi: 10.1097/00003246-199209000-00019.
BACKGROUND AND METHODS
Fructose-1,6-bisphosphate has been shown to improve the outcome of hypoxic ischemic brain injury in adult rabbits. We wished to see if these results could be extended to a newborn animal. Twenty-four 0- to 3-day-old piglets were randomized to receive 300 mg/kg of fructose-1,6-bisphosphate 5 mins before injury, followed by a continuous infusion of 15 mg/kg/min of fructose-1,6-bisphosphate for the next 90 mins, or the equivalent volume of normal saline. Hypoxic ischemic central nervous system damage was induced by ligating both carotid arteries and reducing their BP to two thirds of the normal value for 30 mins. In the last 15 mins of this 30 mins, the FIO2 was reduced to 0.6. At 30 mins, the piglets were resuscitated with an FIO2 of 1.0, the carotid ligatures were released, and the removed blood was reinfused.
RESULTS
The neurologic examination scores at 1, 2, and 3 days after injury and pathologic examination scores at 3 days after injury were not different in the fructose-1,6-bisphosphate-treated and the control animals.
CONCLUSION
Fructose-1,6-bisphosphate does not ameliorate hypoxic ischemic brain injury in the newborn pig.
背景与方法
已证明1,6-二磷酸果糖可改善成年兔缺氧缺血性脑损伤的预后。我们想看看这些结果是否能推广到新生动物。将24只0至3日龄的仔猪随机分为两组，一组在损伤前5分钟接受300mg/kg的1,6-二磷酸果糖，随后在接下来的90分钟内以15mg/kg/分钟的速度持续输注1,6-二磷酸果糖；另一组接受等量的生理盐水。通过结扎双侧颈动脉并将其血压降至正常值的三分之二持续30分钟来诱导缺氧缺血性中枢神经系统损伤。在这30分钟的最后15分钟，将吸入氧分数降至0.6。30分钟时，仔猪用吸入氧分数为1.0进行复苏，松开颈动脉结扎线，并回输抽出的血液。
结果
1,6-二磷酸果糖治疗组和对照组动物在损伤后1天、2天和3天的神经学检查评分以及损伤后3天的病理学检查评分没有差异。
结论
1,6-二磷酸果糖不能改善新生仔猪的缺氧缺血性脑损伤。
Zotero 插件