Akercan Fuat, Kazandi Mert, Sendag Fatih, Cirpan Teksin, Mgoyi Leila, Terek Mustafa Cosan, Sagol Sermet
Department of Obstetrics and Gynecology, Ege University, Faculty of Medicine, Izmir, Turkey.
J Reprod Med. 2004 May;49(5):368-72.
To determine the value of cervical phosphorylated insulinlike growth factor binding protein-1 (IGFBP-1) in the prediction of preterm labor.
In this prospective study, 77 pregnant women, gestational age 24-36 weeks, were enrolled in the study. Twenty women with completely healthy pregnancies formed the control group. Fifty-seven women with signs and symptoms of preterm labor formed the study group. Phosphorylated IGFBP-1 in cervical secretions was assessed in all patients by using a qualitative, immunochromatographic, 1-step dipstick test. Cervical length was measured by transvaginal sonography.
The IGFBP-1 test was negative in all patients in the control group (n = 20), and all of them delivered after 37 weeks, while the test was positive in 15 of 45 (33.3%) patients in the study group. The correlation between cervical length and gestational age at the time of delivery in patients with a positive phosphorylated IGFBP-1 test (n = 15) was significant (r = .553, P = .03). The sensitivity, specificity, positive predictive value and negative predictive value for the phosphorylated IGFBP-1 test were 78%, 87%, 73% and 90%, respectively.
Use of a 1-step dipstick test for detecting phosphorylated IGFBP-1 in cervical secretions is of value in the prediction of preterm labor. The high negative predictive value of the test may be useful in avoiding unnecessary medical interventions.
确定宫颈磷酸化胰岛素样生长因子结合蛋白-1（IGFBP-1）在预测早产中的价值。
在这项前瞻性研究中，纳入了77例孕周为24 - 36周的孕妇。20例妊娠完全健康的女性组成对照组。57例有早产体征和症状的女性组成研究组。通过定性免疫层析一步法试纸条检测对所有患者宫颈分泌物中的磷酸化IGFBP-1进行评估。经阴道超声测量宫颈长度。
对照组所有患者（n = 20）的IGFBP-1检测均为阴性，且她们均在37周后分娩，而研究组45例患者中有15例（33.3%）检测为阳性。磷酸化IGFBP-1检测阳性患者（n = 15）分娩时宫颈长度与孕周之间的相关性显著（r = 0.553，P = 0.03）。磷酸化IGFBP-1检测的敏感性、特异性、阳性预测值和阴性预测值分别为78%、87%、73%和90%。
使用一步法试纸条检测宫颈分泌物中的磷酸化IGFBP-1对预测早产有价值。该检测较高的阴性预测值可能有助于避免不必要的医疗干预。
