Kormeili T, Yamauchi P S, Lowe N J
UCLA School of Medicine, Santa Monica, CA 90404, U.S.A.
Br J Dermatol. 2004 Jun;150(6):1061-9. doi: 10.1111/j.1365-2133.2004.05940.x.
The growing incidence of cutaneous malignancies each year necessitates the development of new and more effective methods for both the diagnosis and the treatment of cancerous lesions, while assuring better cosmetic results and improving patient satisfaction. With that in mind, the use of topical photodynamic therapy (PDT) has been explored in the treatment as well as the diagnosis of various cutaneous malignancies. Using the intrinsic cellular haem biosynthetic pathway and principles of photoillumination, topical PDT carries the goal of selectively targeting abnormal cells, while preserving the normal surrounding structures. This paper will discuss the various applications and data on the use of topical PDT in dermatology.
每年皮肤恶性肿瘤的发病率不断上升，这就需要开发新的、更有效的方法来诊断和治疗癌性病变，同时确保更好的美容效果并提高患者满意度。考虑到这一点，人们已经在各种皮肤恶性肿瘤的治疗和诊断中探索了局部光动力疗法（PDT）的应用。利用细胞内固有的血红素生物合成途径和光照原理，局部光动力疗法的目标是选择性地靶向异常细胞，同时保留周围的正常结构。本文将讨论局部光动力疗法在皮肤科的各种应用及相关数据。
