North Thomas W, Sequar Getachew, Townsend Leroy B, Drach John C, Barry Peter A
Center for Comparative Medicine, University of California-Davis, Davis, CA 95616, USA.
Antimicrob Agents Chemother. 2004 Jul;48(7):2760-5. doi: 10.1128/AAC.48.7.2760-2765.2004.
Rhesus and human cytomegalovirus (RhCMV and HCMV, respectively) exhibit comparable inhibition by benzimidazole nucleosides, including 2,5,6-trichloro-(1-beta-d-ribofuranosyl)benzimidazole (TCRB), and pyrrolo[2,3-d]pyrimidines. The two HCMV protein targets of TCRB, UL89 and UL56, are highly conserved with their RhCMV homologues. These data indicate that infection of rhesus macaques with RhCMV represents a useful model to test novel anti-HCMV drugs.
恒河猴巨细胞病毒和人类巨细胞病毒（分别为RhCMV和HCMV）对包括2,5,6-三氯-（1-β-D-呋喃核糖基）苯并咪唑（TCRB）和吡咯并[2,3-d]嘧啶在内的苯并咪唑核苷表现出相似的抑制作用。TCRB的两个HCMV蛋白靶点UL89和UL56与其RhCMV同源物高度保守。这些数据表明，用RhCMV感染恒河猴是测试新型抗HCMV药物的有用模型。
