Ottenbacher Kenneth J, Ostir Glenn V, Peek M Kristen, Markides Kyriakos S
UT301 University Blvd., Galveston, TX 77555-1137, USA.
J Gerontol A Biol Sci Med Sci. 2004 Jun;59(6):M640-5. doi: 10.1093/gerona/59.6.m640.
Little is known regarding diabetes mellitus as a risk factor for stroke incidence and death in older Mexican Americans. The authors studied diabetes and other potential risk factors for stroke in a sample of community-dwelling older Mexican Americans.
A prospective cohort design was used that involved the Hispanic Established Population for the Epidemiologic Study of the Elderly, a longitudinal study using a weighted probability sample of Mexican Americans (aged older than 65 years) living in the southwestern United States. 3050 older Mexican American persons were originally interviewed and tested at baseline and then followed with reassessment at 2, 5, and 7 years. The incidence of stroke and stroke death were studied for the participants during a 7-year follow-up period.
690 participants were identified at baseline with diabetes. 238 participants experienced a first-time stroke during the follow-up period. 66 died as a result of a stroke. Cox proportional hazard regression analysis revealed an increased hazard ratio (HR) for stroke in persons with diabetes (HR, 1.80; 95% confidence interval [CI], 1.32 to 2.44; p <.0002) when adjusted for age, sex, body mass index, smoking, systolic blood pressure, previous heart attack, and lower extremity function. The stroke mortality rate was also higher (HR, 2.02; 95% CI, 1.04 to 3.93) for persons with diabetes when adjusted for covariates.
Diabetes was associated with an increased incidence of stroke and death in older Mexican Americans, particularly those taking insulin.
关于糖尿病作为墨西哥裔美国老年人中风发病率和死亡率的危险因素，人们了解甚少。作者在一组居住在社区的墨西哥裔美国老年人样本中研究了糖尿病及其他中风潜在危险因素。
采用前瞻性队列设计，涉及西班牙裔老年人流行病学研究的既定人群，这是一项对居住在美国西南部的墨西哥裔美国人（年龄大于65岁）采用加权概率抽样的纵向研究。最初对3050名墨西哥裔美国老年人进行了基线访谈和测试，然后在2年、5年和7年时进行重新评估。在7年随访期内研究了参与者的中风发病率和中风死亡率。
690名参与者在基线时被确定患有糖尿病。238名参与者在随访期间首次中风。66人死于中风。在对年龄、性别、体重指数、吸烟、收缩压、既往心脏病发作和下肢功能进行调整后，Cox比例风险回归分析显示糖尿病患者中风的风险比（HR）增加（HR，1.80；95%置信区间[CI]，1.32至2.44；p<.0002）。在对协变量进行调整后，糖尿病患者的中风死亡率也更高（HR，2.02；95%CI，1.04至3.93）。
糖尿病与墨西哥裔美国老年人中风发病率和死亡率增加相关，尤其是那些使用胰岛素的患者。
