Mikov Momir, Kevresan Slavko, Kuhajda Ksenija, Jakovljević Vida, Vasović Velibor
Institute of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, 21000, Serbia and Montenegro.
Pol J Pharmacol. 2004 May-Jun;56(3):367-71.
The aim of the study was to test the efficacy of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate as a blood-brain barrier (BBB) permeator by examining its effect on quinine uptake into the central nervous system in rats, analgesic action of morphine, and on the sleeping time induced by pentobarbital. The obtained results indicate that sodium 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate can be considered as modifier of BBB permeability, as it exhibited a promoting effect in all three tests. In the test of quinine uptake, methyl ester of 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanoic acid (included in the study for comparison) did not show a promoting effect, which can suggest its specific action.
本研究的目的是通过检测3α,7α-二羟基-12-氧代-5β-胆烷酸对大鼠中枢神经系统中奎宁摄取、吗啡镇痛作用以及戊巴比妥诱导睡眠时间的影响，来测试其作为血脑屏障（BBB）渗透剂的功效。所得结果表明，3α,7α-二羟基-12-氧代-5β-胆烷酸钠可被视为血脑屏障通透性的调节剂，因为它在所有三项测试中均表现出促进作用。在奎宁摄取测试中，3α,7α-二羟基-12-氧代-5β-胆烷酸甲酯（纳入研究用于比较）未显示出促进作用，这可能表明其具有特定作用。
