Ohta Yoshio, Yamaki Kohji, Osawa Toshihiko, Kawakishi Shunro
Hiroshima Prefectural Food Technology Research Center, Hiroshima, Japan.
Biosci Biotechnol Biochem. 2004 Jun;68(6):1375-8. doi: 10.1271/bbb.68.1375.
The effects of isothiocyanates (ITCs) on tumor necrosis factor-alpha (TNF-alpha) production by the J774A.1 mouse macrophage cell line stimulated with lipopolysaccharide (LPS) were examined. Some individual ITCs examined showed a priming effect, which was expressed as pre-activation, but also inhibited the production of TNF-alpha with concomitant stimulation by LPS, as a triggering stimulant of TNF production. These results suggest that ITCs exert opposing activities that can enhance or inhibit the host defense system.
研究了异硫氰酸盐（ITCs）对经脂多糖（LPS）刺激的J774A.1小鼠巨噬细胞系产生肿瘤坏死因子-α（TNF-α）的影响。所检测的一些单个ITCs显示出一种启动效应，表现为预激活，但同时也抑制了由LPS作为TNF产生的触发刺激物伴随刺激时TNF-α的产生。这些结果表明，ITCs发挥着相反的作用，既能增强也能抑制宿主防御系统。
