Alvarez-Olmos Martha I, Barousse Melissa M, Rajan Latta, Van Der Pol Barbara J, Fortenberry Dennis, Orr Donald, Fidel Paul L
Pediatric Infectious Diseases Fellowship Program, Department of Pediatrics, Tulane University Health Sciences Center and Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
Sex Transm Dis. 2004 Jul;31(7):393-400. doi: 10.1097/01.olq.0000130454.83883.e9.
The objective of this study was to survey middle adolescents for the presence of vaginal lactobacilli, lactobacilli-specific immune sensitization, and correlates of vaginal immunity with lactobacilli and bacterial vaginosis (BV).
A cohort of 89 female adolescents were evaluated for the presence of vaginal lactobacilli species, H2O2-producing species, and the prevalence of BV. Cytokines and antibodies in cervicovaginal lavages were detected and peripheral blood lymphocyte (PBL) responses to Lactobacillus crispatus were evaluated.
The majority of lactobacillus species were H2O2-producing and predominated by Lactobacillus acidophilus. PBL responses to lactobacilli were detectable in 50% of the cohort. BV was present in 36% of adolescents and negatively correlated with the presence of vaginal lactobacilli. The majority of locally associated cytokines and antibodies were similar in those with or without BV or lactobacilli.
Adolescents harbor vaginal lactobacilli with relationships to BV along with lactobacilli-specific immune sensitization, but with few correlates of local immunity to lactobacilli or BV.
本研究旨在调查青少年中期女性阴道内乳酸杆菌的存在情况、乳酸杆菌特异性免疫致敏情况，以及阴道免疫力与乳酸杆菌和细菌性阴道病（BV）的相关性。
对89名女性青少年组成的队列进行评估，检测阴道乳酸杆菌种类、产H2O2的种类以及BV的患病率。检测宫颈阴道灌洗液中的细胞因子和抗体，并评估外周血淋巴细胞（PBL）对卷曲乳酸杆菌的反应。
大多数乳酸杆菌种类能产H2O2，且嗜酸乳杆菌占主导。50%的队列中可检测到PBL对乳酸杆菌的反应。36%的青少年存在BV，且与阴道乳酸杆菌的存在呈负相关。大多数局部相关的细胞因子和抗体在有或没有BV或乳酸杆菌的人群中相似。
青少年阴道内存在与BV相关的乳酸杆菌以及乳酸杆菌特异性免疫致敏，但局部对乳酸杆菌或BV的免疫力相关性较小。
