Chen Fang-Yi, Sheu Bor-Ching, Lin Ming-Chieh, Chow Song-Nan, Lin Ho-Hsiung
Department of Obstetrics and Gynecology, National Taiwan University Hospital and College of Medicine, No. 7 Chung-Shan S. Road, Taipei 100, Taiwan.
J Formos Med Assoc. 2004 May;103(5):388-91.
Sertoli-Leydig cell tumors of the ovary are rare diseases that occur primarily in young women. The majority of these tumors are unilaterally localized, and conservative surgery is sufficient. However, these tumors exhibit a variety of histological patterns, which are significant prognostic factors. To date, no standard therapy exists. Here we report 4 cases of Sertoli-Leydig cell tumors of the ovary. One patient whose tumor was a poorly differentiated Sertoli-Leydig cell tumor with mesenchymal heterologous elements received adjuvant chemotherapy postoperatively but died of disease 2.5 years after surgery. The other 3 patients remained free of disease during follow-up. Conservative surgery is an appropriate treatment for young patients with Sertoli-Leydig cell tumors. Those who have poor prognostic factors may need adjuvant chemotherapy with a combination of bleomycin, etoposide and cisplatin.
卵巢支持-间质细胞瘤是一种主要发生于年轻女性的罕见疾病。这些肿瘤大多单侧局限，保守手术即可。然而，这些肿瘤呈现出多种组织学模式，而这些模式是重要的预后因素。迄今为止，尚无标准治疗方法。在此，我们报告4例卵巢支持-间质细胞瘤。1例患者的肿瘤为伴有间叶性异源性成分的低分化支持-间质细胞瘤，术后接受了辅助化疗，但术后2.5年死于疾病。另外3例患者在随访期间无疾病复发。保守手术是年轻卵巢支持-间质细胞瘤患者的合适治疗方法。那些预后因素较差的患者可能需要博来霉素、依托泊苷和顺铂联合的辅助化疗。
