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在向食管下括约肌注射Enteryx失败后进行腹腔镜下尼森胃底折叠术。

Laparoscopic Nissen fundoplication after failure of Enteryx injection into the lower esophageal sphincter.

作者信息

El Nakadi I, Closset J, De Moor V, Coppens E, Zalcman M, Devière J, Gelin M

机构信息

Department of Digestive Surgery, Erasme Hospital, 808 Route de Lennik, 1070, Brussels, Belgium.

出版信息

Surg Endosc. 2004 May;18(5):818-20. doi: 10.1007/s00464-003-9189-3.

DOI:10.1007/s00464-003-9189-3
PMID:15216865
Abstract

BACKGROUND

We investigated the feasibility, safety, and efficacy of laparoscopic antireflux surgery (LARS) after failure of Enteryx injection in the lower esophageal sphincter for the treatment of gastroesophageal reflux disease (GERD).

METHODS

Four patients underwent LARS after failure of Enteryx injection. Particular care was taken during the procedure to identify unusual material or fibrosis.

RESULTS

All patients underwent LARS successfully. In three patients, tight adhesions with fibrous tissues and black foreign material were observed around the esophagus. No complications occurred during the procedures. The postoperative period was uneventful and functional results were excellent.

CONCLUSION

LARS following Enteryx injection is feasible. Careful dissection is mandatory to avoid operative complications. Both techniques may be considered as options for treating GERD.

摘要

背景

我们研究了在食管下括约肌注射Enteryx治疗胃食管反流病(GERD)失败后,腹腔镜抗反流手术(LARS)的可行性、安全性和有效性。

方法

4例患者在Enteryx注射失败后接受了LARS。手术过程中特别注意识别异常物质或纤维化。

结果

所有患者均成功接受了LARS。3例患者在食管周围观察到与纤维组织紧密粘连和黑色异物。手术过程中未发生并发症。术后恢复顺利,功能结果良好。

结论

Enteryx注射后行LARS是可行的。必须仔细解剖以避免手术并发症。这两种技术均可视为治疗GERD的选择。

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本文引用的文献

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Endoscopic anti-reflux procedures.内镜抗反流手术
Gastrointest Endosc. 2002 Nov;56(5):625-8. doi: 10.1016/s0016-5107(02)70107-7.
2
Endoscopic augmentation of the cardia with a biocompatible injectable polymer (Enteryx) in a porcine model.在猪模型中使用生物相容性可注射聚合物(Enteryx)进行内镜下贲门增强术。
Surg Endosc. 2002 Mar;16(3):386-91. doi: 10.1007/s004640080189. Epub 2001 Dec 17.
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Endoscopic implantation of a biopolymer in the lower esophageal sphincter for gastroesophageal reflux: a pilot study.
Curr Treat Options Gastroenterol. 2006 Feb;9(1):59-68. doi: 10.1007/s11938-006-0024-5.
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Endoluminal therapy for gastroesophageal reflux disease: is the evidence for efficacy any stronger?胃食管反流病的腔内治疗:疗效证据是否更充分?
Curr Gastroenterol Rep. 2005 Jun;7(3):202-6. doi: 10.1007/s11894-005-0035-8.
Gastrointest Endosc. 2002 Mar;55(3):335-41. doi: 10.1067/mge.2002.121596.
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An experimental endoscopic technique for reversing gastroesophageal reflux in dogs by injecting inert material in the distal esophagus.
Gastrointest Endosc. 1984 Oct;30(5):275-80. doi: 10.1016/s0016-5107(84)72417-5.