González Pedraza Avilés Alberto, Sánchez Hernández Gabriela, Ponce Rosas Raúl Efrén
Clinica de Medicina Familiar Dr. Ignacio Chávez, ISSSTE, México, DF.
Ginecol Obstet Mex. 2004 Feb;72:68-75.
Recent studies associate Escherichia coli with symptomatic infections at vaginal level, mainly associated to changes in the normal flora taken place by a series of factors characteristic of the host. To recognize their colonization frequency and these factors, it becomes important due to their association with perinatal complications, besides considering this colonization like the critical step preceding urinary tract infection.
To determine the frequency of colonization of Escherichia coli in 519 female patients, the role of the bacterium in the vaginal ecology likes probable cause of clinical manifestations and to recognize the associate's factors of risk with its vaginal colonization.
519 women were studied: 350 symptomatic and 169 asymptomatic. Vaginal swab specimens were inoculated onto the routine mediums. Associations of Escherichia coli with various risk factors were examined by using odds ratios (ORs) and 95% confidence intervals, and statistical significance was assessed by the Chi statistic or Fischer's exact test.
Overall Escherichia coli was isolated from 95 (18.3%) of the women. Factors that were significantly associated with vaginal carriage of E. coli were the age extreme groups, the climacteric, and the bad genital habits.
The highest frequency of vaginal colonization for Escherichia coli was presented in the population groups where there is hormonal deficiency, mainly of estrogens of the type estradiol. The vaginal colonization for E. coli doesn't associate to sexual behavior. Although E. coli doesn't produce defined symptoms at vaginal level, the relatively low carriage rate indicates that this organism should not be considered as part of the normal indigenous vaginal flora and that it should take into account due to the perinatal complication it is associated.
近期研究表明，大肠杆菌与阴道部位的症状性感染有关，主要与宿主一系列特征性因素导致的正常菌群变化有关。鉴于其与围产期并发症的关联，以及将这种定植视为尿路感染之前的关键步骤，认识其定植频率和这些因素变得很重要。
确定519例女性患者中大肠杆菌的定植频率，该细菌在阴道生态中作为临床表现可能原因的作用，并识别与其阴道定植相关的危险因素。
对519名女性进行了研究：350名有症状者和169名无症状者。阴道拭子标本接种于常规培养基上。使用优势比（OR）和95%置信区间检查大肠杆菌与各种危险因素的关联，并通过卡方统计或费舍尔精确检验评估统计学意义。
总体而言，95名（18.3%）女性分离出大肠杆菌。与大肠杆菌阴道携带显著相关的因素是年龄极端组、更年期和不良生殖习惯。
大肠杆菌阴道定植的最高频率出现在激素缺乏的人群组中，主要是雌二醇类型的雌激素缺乏。大肠杆菌的阴道定植与性行为无关。虽然大肠杆菌在阴道水平不会产生明确症状，但相对较低的携带率表明该微生物不应被视为正常阴道固有菌群的一部分，并且鉴于其与围产期并发症的关联应予以考虑。
