Yazbeck C, Dhainaut C, Batallan A, Thoury A, Madelenat P
Service de gynécologie-obstétrique, hôpital Bichat-Claude-Bernard, Paris, France.
Gynecol Obstet Fertil. 2004 Jun;32(6):556-61. doi: 10.1016/j.gyobfe.2004.04.007.
A reasonable assumption is that incontinence would be relieved by increasing urethral resistance through stimulating alpha-adrenergic receptors in urethral smooth muscle. A review of available medical treatment of stress urinary incontinence is done. Alpha-receptor agonists are not in common use because of systemic side-effects. Estrogens do not seem to have beneficial effect on stress urinary incontinence. Currently, new molecules such as duloxetine, are uptake inhibitor of serotonin and noradrenaline could provide a noninvasive therapy for patients with urinary incontinence. Further studies to identify clinical applications are required.