Basterrechea M A, de Arriba G, García-Martín F, Sánchez-Heras M, Giménez-Vega E, Sánchez J
Sección de Nefrología, Hospital Universitario de Guadalajara, Departamento de Medicina, Universidad de Alcalá.
Nefrologia. 2004;24(2):183-7.
We describe three patients with minimal change nephrotic syndrome associated with penicillamine treatment. Two patients had systemic sclerosis and one had rheumatoid arthritis. Cumulative dose of D-penicillamine was similar in all cases, and nephrotic syndrome appeared after 15-33 months of treatment. The drug was stopped and nephrotic syndrome disappeared in 2-4 months, suggesting a possible causal relationship between penicillamine and minimal change disease.
