Shortkroff Sonya, Binello Emanuela, Zhu Xuping, Gierga David, Thornhill Thomas S, Shefer Ruth E, Jones Alun G, Yanch Jacquelyn C
Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
Nucl Med Biol. 2004 Jul;31(5):663-70. doi: 10.1016/j.nucmedbio.2003.12.001.
This study assessed the treatment with boron neutron capture synovectomy of synovitis in the antigen-induced arthritis (AIA) model. A boron compound, potassium dodecahydrododeca-borate (K(2)B(12)H(12)), was injected into stifle joints of 24 AIA and 12 normal rabbits and activated by neutron bombardment of the joint to achieve doses from 800 to 81,000 RBE-cGy. Synovial ablation in the AIA joint was accomplished at doses of 6,000 to 7,000 RBE-cGy with no adverse effects to skin or extracapsular tissues.
本研究评估了硼中子俘获滑膜切除术治疗抗原诱导性关节炎（AIA）模型中的滑膜炎。将一种硼化合物十二氢十二硼酸钾（K₂B₁₂H₁₂）注入24只AIA兔和12只正常兔的膝关节，并通过对关节进行中子轰击来激活，以达到800至81,000拉德生物效应剂量（RBE - cGy）的剂量。在AIA关节中，6,000至7,000拉德生物效应剂量（RBE - cGy）的剂量可实现滑膜切除，且对皮肤或关节囊外组织无不良影响。
