Colby Suzanne M, Rohsenow Damaris J, Monti Peter M, Gwaltney Chad J, Gulliver Suzy B, Abrams David B, Niaura Raymond S, Sirota Alan D
Center for Alcohol and Addiction Studies, Brown University, Box G-BH, Providence, RI 02912, USA.
Addict Behav. 2004 Jul;29(5):879-92. doi: 10.1016/j.addbeh.2004.03.002.
Nicotine and alcohol may have common neurobiological mechanisms of reinforcement. Therefore, withholding one substance might result in compensatory increases in self-administration of the other. This laboratory study investigated the effects of brief tobacco deprivation on alcohol cue-elicited urges to drink, corresponding psychophysiological reactions, and alcohol consumption. Young adults (N=78) who were moderate to heavy smokers and drinkers were stratified and randomized to a 2 x 2 design. Participants were either deprived of tobacco for 5 h or not deprived and then exposed to in vivo alcohol or control beverage cues. Subsequently, participants engaged in a taste-rating task as an unobtrusive measure of alcohol consumption. Tobacco deprivation resulted in increased urge to smoke and decreased cardiovascular responses but did not increase alcohol urges or alcohol consumption. Results indicate that brief tobacco deprivation does not result in compensatory increases in alcohol consumption among young moderate to heavy drinkers.
尼古丁和酒精可能具有共同的强化神经生物学机制。因此，戒断一种物质可能会导致另一种物质的自我给药量出现代偿性增加。这项实验室研究调查了短期烟草戒断对酒精线索诱发的饮酒冲动、相应的心理生理反应以及酒精摄入量的影响。将中度至重度吸烟和饮酒的年轻成年人（N = 78）进行分层并随机分配到2×2设计中。参与者要么被剥夺烟草5小时，要么未被剥夺，然后接触体内酒精或对照饮料线索。随后，参与者进行了一项口味评分任务，作为对酒精摄入量的一种不显眼的测量方法。烟草戒断导致吸烟冲动增加和心血管反应降低，但并未增加饮酒冲动或酒精摄入量。结果表明，短期烟草戒断不会导致年轻的中度至重度饮酒者的酒精摄入量出现代偿性增加。
