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钍造影剂诱发的骨髓发育异常患者的全身病理分析。

Whole-body pathologic analysis of a patient with Thorotrast-induced myelodysplasia.

作者信息

Graham S J, Heaton R B, Garvin D F, Cotelingam J D

机构信息

Department of Pathology, National Naval Medical Center, Bethesda, MD 20814-5000.

出版信息

Health Phys. 1992 Jul;63(1):20-6. doi: 10.1097/00004032-199207000-00003.

DOI:10.1097/00004032-199207000-00003
PMID:1522005
Abstract

An autopsy was performed on a 72-y-old Caucasian female who had received a carotid artery injection of thorium dioxide in 1953. The body was dissected in such a manner as to provide for radiobiological evaluation as well as to determine histologically the distribution of Thorotrast in the tissues and its complications. Thorotrast was identified within the liver, spleen, lymph nodes, bone marrow, and surrounding the right carotid artery (the injection site). The cause of death was gastric hemorrhage complicating pancytopenia secondary to refractory anemia with excess of blasts (myelodysplastic syndrome).

摘要

对一名72岁的白种女性进行了尸检,该女性在1953年接受了二氧化钍颈动脉注射。解剖尸体的方式既能进行放射生物学评估,又能从组织学上确定钍造影剂在组织中的分布及其并发症。在肝脏、脾脏、淋巴结、骨髓以及右颈动脉(注射部位)周围发现了钍造影剂。死亡原因是胃出血,这是难治性贫血伴原始细胞增多(骨髓增生异常综合征)继发全血细胞减少的并发症。

相似文献

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Whole-body pathologic analysis of a patient with Thorotrast-induced myelodysplasia.钍造影剂诱发的骨髓发育异常患者的全身病理分析。
Health Phys. 1992 Jul;63(1):20-6. doi: 10.1097/00004032-199207000-00003.
2
The distribution of Thorotrast in human bone marrow: a case report.钍造影剂在人骨髓中的分布:一例报告。
Health Phys. 1992 Jul;63(1):46-53. doi: 10.1097/00004032-199207000-00007.
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Clinical consequences of Thorotrast in a long-term survivor.钍造影剂在一名长期存活者中的临床后果。
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Clinicopathological study of hematological disorders after Thorotrast administration in Japan.日本钍造影剂注射后血液系统疾病的临床病理研究
Blut. 1988 Apr;56(4):153-60. doi: 10.1007/BF00320745.
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Thorotrast granuloma of the neck with local complications.颈部钍造影剂肉芽肿伴局部并发症
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Cancer risk following exposure to Thorotrast: overview in relation to a case report.接触钍造影剂后的癌症风险:与一例病例报告相关的概述
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Epidemiological follow-up study of Japanese Thorotrast cases--1980.
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Comprehensive evaluation of a Thorotrast patient: an overview.钍造影剂患者的综合评估:概述
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[An autopsy case of dysmyelopoietic syndrome with marked chromosomal abnormalities induced by thorotrast].[钍造影剂诱发的伴有明显染色体异常的骨髓生成异常综合征尸检病例]
Rinsho Ketsueki. 1985 Oct;26(10):1641-6.

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