Priest N D, Humphreys J A, Kathren R L, Mays C W
Harwell Biomedical Research, AEA Environment and Energy, Oxfordshire, United Kingdom.
Health Phys. 1992 Jul;63(1):46-53. doi: 10.1097/00004032-199207000-00007.
Samples of bone containing cellular and fatty bone marrow were removed at autopsy from the body of a woman who, following an automobile accident, had been injected with approximately 25 mL of the radiographic contrast medium Thorotrast. The woman survived for 36 y after the accident and died at age 72 y following bone marrow failure. The samples were analyzed to determine their thorium content by x-ray fluorescence and by image analysis. In addition, Thorotrast was visualized in the different bones examined by light microscopy and by backscattered electron imaging with a scanning electron microscope. The results showed Thorotrast to be largely restricted to areas of cellular bone marrow. In such regions, Thorotrast was present throughout the marrow tissue and was also concentrated within cells that were commonly aggregated within focalized areas of the marrow. Overall the results suggest a rather uniform pattern of Thorotrast uptake by the red bone marrow at different skeletal sites. Significant deposits of Thorotrast were not found in fatty yellow marrow. We conclude that Thorotrast-derived risk estimates for human leukemia following high LET, alpha irradiation may be used for calculating the risks of alpha exposure, but with caution.
从一名女性尸体的尸检中获取了含有细胞性和脂肪性骨髓的骨样本。该女性在遭遇汽车事故后，被注射了约25毫升的放射性造影剂钍造影剂。事故发生后，该女性存活了36年，最终在72岁时因骨髓衰竭死亡。通过X射线荧光分析和图像分析对样本进行了分析，以确定其钍含量。此外，通过光学显微镜和扫描电子显微镜的背散射电子成像，在检查的不同骨骼中观察到了钍造影剂。结果显示，钍造影剂主要局限于细胞性骨髓区域。在这些区域，钍造影剂存在于整个骨髓组织中，并且还集中在通常聚集在骨髓局部区域内的细胞中。总体而言，结果表明不同骨骼部位的红骨髓对钍造影剂的摄取模式相当一致。在脂肪性黄骨髓中未发现大量的钍造影剂沉积。我们得出结论，对于高传能线密度α辐射后人类白血病的钍造影剂衍生风险估计，可用于计算α暴露风险，但需谨慎使用。
