Gao Liang-Hui, Zheng Shu-Sen
Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University, PO Box 4193, Hubin Campus, 353 Yan'an Road, Hangzhou 310031, Zhejiang Province, China.
World J Gastroenterol. 2004 Jul 1;10(13):1857-61. doi: 10.3748/wjg.v10.i13.1857.
Cytomegalovirus (CMV) remains one of the most frequent viral infections and the most common cause of death after liver transplantation (LT). Chronic allograft liver rejection remains the major obstacle to long-term allograft survival and CMV infection is one of the suggested risk factors for chronic allograft rejection. The precise relationship between cytomegalovirus and chronic rejection remains uncertain. This review addresses the morbidity of cytomegalovirus infection and the risk factors associated with it, the relationship between cytomegalovirus and chronic allograft liver rejection and the potential mechanisms of it.
巨细胞病毒(CMV)仍然是最常见的病毒感染之一,也是肝移植(LT)后最常见的死亡原因。慢性移植肝排斥反应仍然是长期移植肝存活的主要障碍,而CMV感染是慢性移植肝排斥反应的潜在危险因素之一。巨细胞病毒与慢性排斥反应之间的确切关系尚不确定。本文综述了巨细胞病毒感染的发病率及其相关危险因素、巨细胞病毒与慢性移植肝排斥反应之间的关系及其潜在机制。