HIV感染期间自然杀伤细胞功能和受体的扰动。
Perturbation of natural killer cell function and receptors during HIV infection.
作者信息
Eger Karla A, Unutmaz Derya
机构信息
Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
出版信息
Trends Microbiol. 2004 Jul;12(7):301-3. doi: 10.1016/j.tim.2004.05.006.
Natural killer (NK) cells play an important role in innate host defenses against a variety of pathogens. A recent report described striking perturbations in the expression of NK cell inhibitory and activating receptors in viremic human immunodeficiency virus (HIV)-infected patients, leading to functional abnormalities in these cells. This finding provides a mechanistic insight into NK cell dysfunction and its possible contribution to the impairment of innate host defenses in HIV-infected individuals.
自然杀伤（NK）细胞在宿主针对多种病原体的固有防御中发挥着重要作用。最近的一份报告描述了病毒血症期人类免疫缺陷病毒（HIV）感染患者中NK细胞抑制性和激活性受体表达的显著紊乱，导致这些细胞出现功能异常。这一发现为NK细胞功能障碍及其可能对HIV感染个体固有宿主防御受损的影响提供了机制性见解。
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