Wilson Rhoda, Jenkins Carol, Miller Helen, McInnes Iain B, Moore Judith, McLean Marjorie A, Walker James J
University Department of Medicine, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, UK.
Eur J Obstet Gynecol Reprod Biol. 2004 Jul 15;115(1):51-4. doi: 10.1016/j.ejogrb.2003.11.029.
To compare cytokine levels in serum from non-pregnant women with a history of recurrent miscarriage with those found in non-pregnant women with no such history.
Two patient groups were enrolled into the study. Group 1 comprised 25 non-pregnant women with no history of recurrent miscarriage. Group 2 comprised 50 non-pregnant women who had a history of at least three previous miscarriages. Fifteen of these women have since become pregnant again--10 had a successful pregnancy and five miscarried. Serum levels of IL-4, IFN gamma, IL-12 and IL-18 were measured.
Results showed IFN gamma ( 0.68 +/- 0.72 versus 0.45 +/- 0.29 P < 0.05) and IL-12 levels (66 +/- 25 versus 51 +/- 24 P < 0.05) were significantly higher in Group 2 compared to Group 1. Levels of IL-18 were significantly lower in Group 2 patients (318 +/- 140 versus 246 +/- 219 P < 0.05). Of the 15 women who became pregnant, those who miscarried again had significantly higher IL-18 levels when not pregnant than those women whose next pregnancies went successfully to term (547 +/- 20 versus 274 +/- 129 P < 0.05).
These results suggest that women with a history of recurrent miscarriage can have abnormal cytokine expression even when not pregnant. This may influence the potential for future successful immune modulatory therapy.
比较有复发性流产史的未孕女性与无此病史的未孕女性血清中的细胞因子水平。
两组患者纳入本研究。第1组包括25名无复发性流产史的未孕女性。第2组包括50名有至少三次既往流产史的未孕女性。其中15名女性后来再次怀孕——10名成功妊娠，5名流产。检测血清中IL-4、IFNγ、IL-12和IL-18的水平。
结果显示，与第1组相比，第2组的IFNγ（0.68±0.72对0.45±0.29，P<0.05）和IL-12水平（66±25对51±24，P<0.05）显著更高。第2组患者的IL-18水平显著更低（318±140对246±219，P<0.05）。在15名再次怀孕的女性中，再次流产的女性在未孕时的IL-18水平显著高于下次妊娠足月的女性（547±20对274±129，P<0.05）。
这些结果表明，有复发性流产史的女性即使在未孕时也可能有异常的细胞因子表达。这可能会影响未来免疫调节治疗成功的可能性。
