Kuśnierczyk Piotr
Laboratorium Immunogenetyki, Zakład Immunologii Klinicznej, Instytut Immunologii i Terapii Doświadczalnej PAN im. Ludwika Hirszfelda we Wrocławiu.
Postepy Hig Med Dosw (Online). 2004 Jun 18;58:259-63.
The genetics and physiological role of killer cell immunoglobulin-like receptors (KIR) are briefly reviewed. Haplotype polymorphism of KIR genes resulting in different proportions of genes coding for activatory and inhibitory receptors is emphasized. The participation of KIR molecules in the reactions of natural killer (NK) cells and subpopulations of T lymphocytes is described. Human diseases, in which a contribution of KIR has been found or suspected are listed. Study designs on KIR for realization in Poland are proposed.
本文简要综述了杀伤细胞免疫球蛋白样受体（KIR）的遗传学及生理作用。重点强调了KIR基因的单倍型多态性，其导致编码激活型和抑制型受体的基因比例不同。描述了KIR分子在自然杀伤（NK）细胞反应及T淋巴细胞亚群中的作用。列出了已发现或怀疑KIR有作用的人类疾病。提出了在波兰开展KIR相关研究的设计方案。
