Birkner Ewa, Zalejska-Fiolka Jolanta, Antoszewski Zygmunt
Zakład Biochemii Ogólnej Katedry Biochemii w Zabrzu Slaskiej Akademii Medycznej.
Postepy Hig Med Dosw (Online). 2004 Jun 18;58:264-9.
Oxidative stress has been implicated in the pathogenesis of certain diseases, such as Alzheimer's disease. Disturbance in the prooxidant/antioxidant balance increases during aging moreover the production of free radicals is alleged to play a significant role in this neurodegenerative process. Because Alzheimer's disease applies to elderly people, the aim of this publication was to explore the connection between oxidative stress and its influence on the aging process. This study refers to recent studies and publications on Alzheimer's disease and particularly the oxidative stress processes connected with this illness. These processes suggest that oxidative damage is one of the factors in the neuronal death underlying the loss of cognition. Researchers involved in these studies describe oxidative damage as increases or decreases in antioxidant enzyme activity, the role of antioxidant vitamin supplementation, and alternative medications targeting other specific areas of activity in Alzheimer's disease prevention and treatment.
氧化应激与某些疾病的发病机制有关，如阿尔茨海默病。衰老过程中促氧化剂/抗氧化剂平衡的紊乱会加剧，而且自由基的产生被认为在这个神经退行性过程中起重要作用。由于阿尔茨海默病多见于老年人，本出版物的目的是探讨氧化应激与其对衰老过程的影响之间的联系。本研究参考了近期关于阿尔茨海默病的研究和出版物，特别是与该疾病相关的氧化应激过程。这些过程表明，氧化损伤是认知丧失背后神经元死亡的因素之一。参与这些研究的人员将氧化损伤描述为抗氧化酶活性的增加或降低、抗氧化维生素补充剂的作用，以及针对阿尔茨海默病预防和治疗中其他特定活性领域的替代药物。
