Watts Colin
Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.
Nat Immunol. 2004 Jul;5(7):685-92. doi: 10.1038/ni1088.
The endosomes and lysosomes of antigen-presenting cells host the processing and assembly reactions that result in the display of peptides on major histocompatibility complex (MHC) class II molecules and lipid-linked products on CD1 molecules. This environment is potentially hostile for T cell epitope and MHC class II survival, and the influence of regulators of protease activity and specialized chaperones that assist MHC class II assembly is crucial. At present, evidence indicates that individual proteases make both constructive and destructive contributions to antigen processing for MHC class II presentation to CD4 T cells. Some features of CD1 antigen capture within the endocytic pathway are also discussed.
抗原呈递细胞的内体和溶酶体承载着加工和组装反应，这些反应导致肽段在主要组织相容性复合体（MHC）II类分子上展示，以及脂质连接产物在CD1分子上展示。这种环境对T细胞表位和MHC II类分子的存活可能具有潜在的不利影响，而蛋白酶活性调节剂和协助MHC II类分子组装的特殊伴侣蛋白的作用至关重要。目前，有证据表明，个别蛋白酶对MHC II类分子呈递给CD4 T细胞的抗原加工既有建设性作用，也有破坏性作用。本文还讨论了内吞途径中CD1抗原捕获的一些特点。
