Middeldorp J M, Klumper F J, Oepkes D, Lopriore E, Kanhai H H, Vandenbussche F P
Afd. Verloskunde, Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden.
Ned Tijdschr Geneeskd. 2004 Jun 12;148(24):1203-8.
Evaluation of the initial results of selective fetoscopic laser coagulation of placental blood vessels for severe second-trimester twin-to-twin transfusion syndrome in the Netherlands.
Prospective cohort study.
Between August 2000 and December 31, 2002, 49 patients were included with severe second-trimester twin-to-twin transfusion syndrome. Treatment took place in the Leiden University Medical Centre and consisted of selective fetoscopic laser coagulation of anastomoses along the vascular equator on the placental surface. Follow-up was complete until six weeks after delivery.
Median gestational age was 20 weeks at fetoscopy and 34 weeks at birth. Perinatal survival rate was 65% (64/98). The treatment resulted in at least one surviving child in 80% of pregnancies.
The results of fetoscopic laser treatment for severe second-trimester twin-to-twin transfusion syndrome in the Netherlands are similar to the recent results in specialised foreign centres.
评估荷兰对孕中期严重双胎输血综合征进行选择性胎儿镜激光凝固胎盘血管的初步结果。
前瞻性队列研究。
在2000年8月至2002年12月31日期间，纳入了49例孕中期严重双胎输血综合征患者。治疗在莱顿大学医学中心进行，包括在胎盘表面沿血管赤道对吻合口进行选择性胎儿镜激光凝固。随访至分娩后六周结束。
胎儿镜检查时的中位孕周为20周，出生时为34周。围产期存活率为65%（64/98）。该治疗使80%的妊娠中至少有一个存活婴儿。
荷兰对孕中期严重双胎输血综合征进行胎儿镜激光治疗的结果与国外专业中心的近期结果相似。
