模块化生物体内的空间相互作用：遗传异质性与生物体适应性。

Spatial interactions within modular organisms: genetic heterogeneity and organism fitness.

作者信息

Pineda-Krch Mario, Poore Alistair G B

机构信息

Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver BC, Canada V6J IV9.

出版信息

Theor Popul Biol. 2004 Aug;66(1):25-36. doi: 10.1016/j.tpb.2004.03.002.

DOI:10.1016/j.tpb.2004.03.002

PMID:15225573

Abstract

Modular organisms are composed of iterated units of construction that vary in their spatial arrangement. This variation is expected to affect the fitness of modular organisms due to interactions among neighboring modules and the potential for such organisms to be genetically heterogeneous. We devise a spatially explicit model to investigate how spatial interactions among neighboring modules affect organism fitness. We show that fitness is strongly dependent on the spatial arrangement of modules in both genetically homogeneous and heterogeneous organisms, and that the magnitude of the variation is dependent on the strength of interactions among modules. Organism fitness is more variable with interactions among modules that are symmetrical (each affects each other in the same directions) than with asymmetrical interactions (neighbors affect each other in different directions). We conclude by discussing potential extension of the present framework to a general dynamic model of spatially structured organism development.

摘要

模块化生物由重复的构建单元组成，这些单元在空间排列上有所不同。由于相邻模块之间的相互作用以及此类生物具有基因异质性的可能性，这种变化预计会影响模块化生物的适应性。我们设计了一个空间明确的模型，以研究相邻模块之间的空间相互作用如何影响生物适应性。我们表明，在基因同质和异质的生物中，适应性都强烈依赖于模块的空间排列，并且变化的幅度取决于模块之间相互作用的强度。与不对称相互作用（邻居在不同方向上相互影响）相比，模块之间对称相互作用（每个模块在相同方向上相互影响）时，生物适应性的变化更大。我们通过讨论将当前框架潜在扩展为空间结构生物发育的一般动态模型来得出结论。