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对称双炔基或烷基吡啶与噻吩衍生物的合成及其抗血管生成活性。

Synthesis of symmetrical bis-alkynyl or alkyl pyridine and thiophene derivatives and their antiangiogenic activities.

作者信息

Ahn Chan Mug, Shin Woon-Seob, Bum Woo Ho, Lee Seokjoon, Lee Hyean-Woo

机构信息

Department of Basic Sciences, Wonju College of Medicine, Yonsei University, Wonju 220-701, South Korea.

出版信息

Bioorg Med Chem Lett. 2004 Aug 2;14(15):3893-6. doi: 10.1016/j.bmcl.2004.05.065.

DOI:10.1016/j.bmcl.2004.05.065
PMID:15225692
Abstract

Fourteen symmetrical bis-alkynyl pyridine and thiophene derivatives were synthesized and their antiangiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells (HUVEC). Compounds 6, 8, and 10, rigid mimetic structure of curcumin, showed the potent growth inhibitory activity and the potent tube formation inhibitory activity.

摘要

合成了14种对称的双炔基吡啶和噻吩衍生物，并通过对人脐静脉内皮细胞（HUVEC）的增殖和管形成抑制活性评估了它们的抗血管生成活性。化合物6、8和10具有姜黄素的刚性模拟结构，表现出强大的生长抑制活性和强大的管形成抑制活性。

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