1,25 - 二羟维生素D对骨骼的直接作用：维生素D受体敲除小鼠（VDRKO）的骨骼在正常矿物质条件下显示出过度的骨形成。

Direct action of 1,25-dihydroxyvitamin D on bone: VDRKO bone shows excessive bone formation in normal mineral condition.

作者信息

Tanaka Hiroyuki, Seino Yoshiki

机构信息

Department of Pediatrics, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

出版信息

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):343-5. doi: 10.1016/j.jsbmb.2004.03.021.

DOI:10.1016/j.jsbmb.2004.03.021

PMID:15225798

Abstract

In the present study, the direct role of Vitamin D in bone metabolism was investigated. Vitamin D has been suggested to be an important hormone for bone metabolism, but there has been little evidence that Vitamin D actively participates in this process. Here, we show the direct action of Vitamin D by transplanting the bone of the Vitamin D receptor null mutant mice (VDR-/-) to the wild-type mouse. This procedure allowed us to investigate the changes in the bone without VDR in the normal humoral environment. Unexpectedly, the volume and the density of the VDR-/- bone transplanted to the wild-type mouse were significantly increased compared with the control (wild-type bone transplanted to the wild-type mouse). We show that Vitamin D has key roles in bone metabolism negatively.

摘要

在本研究中，对维生素D在骨代谢中的直接作用进行了研究。维生素D被认为是骨代谢的一种重要激素，但几乎没有证据表明维生素D积极参与这一过程。在此，我们通过将维生素D受体基因敲除突变小鼠（VDR-/-）的骨移植到野生型小鼠体内，展示了维生素D的直接作用。这一操作使我们能够在正常体液环境中研究缺乏VDR的骨的变化。出乎意料的是，移植到野生型小鼠体内的VDR-/-骨的体积和密度与对照组（野生型骨移植到野生型小鼠体内）相比显著增加。我们表明维生素D在骨代谢中起负向关键作用。