c-myc和p53在头颈部鳞状细胞癌中的表达的临床意义

Clinical significance of c-myc and p53 expression in head and neck squamous cell carcinomas.

作者信息

Waitzberg Angela F L, Nonogaki Suely, Nishimoto Inês N, Kowalski Luiz P, Miguel Roberto E V, Brentani Ricardo R, Brentani M M

机构信息

Universidade Federal de São Paulo, São Paulo, Brazil.

出版信息

Cancer Detect Prev. 2004;28(3):178-86. doi: 10.1016/j.cdp.2004.02.003.

DOI:10.1016/j.cdp.2004.02.003

PMID:15225897

Abstract

c-myc and p53 genes were frequently deregulated in head and neck squamous cell carcinoma (HNSCC). To determine if the concomitant expression of the two oncogenes might have prognostic value, the survival and free disease time of 140 consecutive HNSCC patients followed up for a median time of 29.9 months was analyzed in the light of p53 and c-myc expression assessed by immunohistochemistry. Positive c-myc and p53 staining was detected respectively in 35.7 and 50.7% of the tumors. Double positivity emerged in 16.4% of the cases. Overall-survival of patients was not associated with the immunoreactivity of p53 or c-myc considered separately or grouped in subsets. Considering only the advanced stages, the concomitant expression of both oncogenes in tumors was associated with worse disease-free survival (P = 0.004) suggesting a role for p53 and c-myc genes in progression of this HNSCC subset. Clinical parameters (presence of lymph nodes, histologic grade and tumor width) remained important indicators of overall survival (OS).

摘要

c-myc和p53基因在头颈部鳞状细胞癌（HNSCC）中经常发生失调。为了确定这两种癌基因的同时表达是否具有预后价值，根据免疫组织化学评估的p53和c-myc表达，分析了140例连续HNSCC患者的生存情况和无病时间，这些患者的中位随访时间为29.9个月。分别在35.7%和50.7%的肿瘤中检测到c-myc和p53染色阳性。16.4%的病例出现双阳性。患者的总生存率与单独或分组考虑的p53或c-myc免疫反应性无关。仅考虑晚期阶段，肿瘤中两种癌基因的同时表达与较差的无病生存率相关（P = 0.004），提示p53和c-myc基因在该HNSCC亚组进展中起作用。临床参数（淋巴结状态、组织学分级和肿瘤宽度）仍然是总生存（OS）的重要指标。