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4
The tubulin-bound conformation of paclitaxel: T-taxol vs "PTX-NY".
J Nat Prod. 2009 Mar 27;72(3):422-9. doi: 10.1021/np800662j.
5
The taxol pharmacophore and the T-taxol bridging principle.
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Insights into the mechanism of microtubule stabilization by Taxol.
Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10166-10173. doi: 10.1073/pnas.0603704103. Epub 2006 Jun 26.
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Design and synthesis of simplified taxol analogs based on the T-Taxol bioactive conformation.
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8
The T-Taxol conformation.
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The binding conformation of Taxol in beta-tubulin: a model based on electron crystallographic density.
Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5312-6. doi: 10.1073/pnas.051309398. Epub 2001 Apr 17.
10
Synthesis and bioactivity of a side chain bridged paclitaxel: A test of the T-Taxol conformation.
Bioorg Med Chem Lett. 2009 May 15;19(10):2884-7. doi: 10.1016/j.bmcl.2009.03.063. Epub 2009 Mar 21.

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Alcyonacea: A Potential Source for Production of Nitrogen-Containing Metabolites.
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Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery.
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Synthesis and biological analysis of truncated calyculone H.
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Conformationally Constrained and Nanoparticle Targeted Paclitaxels.
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Eliminating the heart from the curcumin molecule: monocarbonyl curcumin mimics (MACs).
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The quest for a simple bioactive analog of paclitaxel as a potential anticancer agent.
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本文引用的文献

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Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.
Nature. 2004 Mar 11;428(6979):198-202. doi: 10.1038/nature02393.
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Modeling the interaction of paclitaxel with beta-tubulin.
Oncol Res. 2003;14(1):1-19. doi: 10.3727/000000003108748568.
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Microtubule structure at 8 A resolution.
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Anticancer therapy with novel tubulin-interacting drugs.
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Refined structure of alpha beta-tubulin at 3.5 A resolution.
J Mol Biol. 2001 Nov 9;313(5):1045-57. doi: 10.1006/jmbi.2001.5077.
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Synthesis and biological evaluation of novel macrocyclic paclitaxel analogues.
Org Lett. 2001 Aug 9;3(16):2461-4. doi: 10.1021/ol016124d.
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Novel d-seco paclitaxel analogues: synthesis, biological evaluation, and model testing.
J Org Chem. 2001 May 18;66(10):3321-9. doi: 10.1021/jo0015467.

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