组织型纤溶酶原激活剂用于冠状动脉溶栓：前瞻性综述。
Coronary thrombolysis with tissue-type plasminogen activator: prospective review.
作者信息
Collen D D
机构信息
Center for Thrombosis and Vascular Research, Department of Medical Research, University of Leuven, Belgium.
出版信息
Tex Heart Inst J. 1984 Dec;11(4):344-7.
Abstract
Coronary thrombolysis is not a goal in itself, but is employed to prevent necrotic dysfunction of jeopardized myocardial cells. It is being increasingly investigated as a treatment for acute myocardial infarction, which is often associated with thrombotic occlusion of an atherosclerotic coronary artery. The administration of thrombolytic agents has been shown to reopen an occluded coronary artery in the majority of such cases. Briefly summarized are studies performed to date in animal models and in patients with acute myocardial infarction.
摘要
冠状动脉溶栓本身并非目的，而是用于预防濒危心肌细胞的坏死性功能障碍。作为急性心肌梗死的一种治疗方法，它正受到越来越多的研究，急性心肌梗死常与动脉粥样硬化性冠状动脉的血栓闭塞有关。在大多数此类病例中，已证明给予溶栓剂可使闭塞的冠状动脉再通。简要总结了迄今为止在动物模型和急性心肌梗死患者中进行的研究。
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