Bergmann S R, Fox K A, Ter-Pogossian M M, Sobel B E, Collen D
Science. 1983 Jun 10;220(4602):1181-3. doi: 10.1126/science.6602378.
Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.
冠状动脉溶栓是一种能够中止急性心肌梗死后遗症的干预措施，通过静脉注射凝块选择性组织型纤溶酶原激活剂，在犬类动物中10分钟内即可完成。除了诱导凝块溶解外，这种有前景的纤溶药物还能恢复中间代谢和心肌营养血流，用正电子断层扫描可无创检测到，且不会诱发全身纤溶状态。
