长期给予右芬氟拉明对盐敏感性大鼠血压的影响。
Effect of chronic administration of dexfenfluramine on blood pressure in salt-sensitive rats.
作者信息
Rowland N E, Fregly M J, Poortman C M, Li H
机构信息
Department of Psychology, University of Florida, Gainesville 32611.
出版信息
Life Sci. 1992;51(13):1021-4. doi: 10.1016/0024-3205(92)90500-o.
PMID:1522751
Abstract
Chronic administration of dexfenfluramine, at a relatively low daily dose, slowed the development of salt-induced elevation of blood pressure in salt-sensitive (Dahl DS and Rapp SS) rats. This effect could not be accounted for by drug-related anorexia alone. Elevated serotonin activity, possibly in the brain, may underlie this antihypertensive action of dexfenfluramine.
摘要
以相对低的日剂量长期给予右芬氟拉明，可减缓盐敏感（Dahl DS和Rapp SS）大鼠因盐诱导的血压升高的发展。这种作用不能仅由与药物相关的厌食来解释。血清素活性升高，可能是在大脑中，可能是右芬氟拉明这种抗高血压作用的基础。
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