Botuha Candice, Galley Carl M S, Gallagher Timothy
School of Chemistry, University of Bristol, Bristol, UKBS8 1TS.
Org Biomol Chem. 2004 Jul 7;2(13):1825-6. doi: 10.1039/b405275g. Epub 2004 Jun 4.
The synthesis of racemic cytisine has been completed using (i)N-selective alkylation of 6-bromopyridone with bromide and (ii) Pd(0) mediated intramolecular alpha-arylation of lactam as key steps to achieve rapid assembly of the tricyclic core skeleton of the lupin alkaloids.
消旋金雀花碱的合成已完成，该合成采用了以下关键步骤：（i）6-溴吡啶酮与溴化物进行N-选择性烷基化反应，以及（ii）钯（0）介导的内酰胺分子内α-芳基化反应，以实现羽扇豆生物碱三环核心骨架的快速组装。
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