(+)-金雀花碱、(-)-毒毛旋花子胺、(-)-异毒毛旋花子胺和(-)-朱西亚因A的合成

Syntheses of (+)-cytisine, (-)-kuraramine, (-)-isokuraramine, and (-)-jussiaeiine A.

作者信息

Honda Toshio, Takahashi Rie, Namiki Hidenori

机构信息

Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.

出版信息

J Org Chem. 2005 Jan 21;70(2):499-504. doi: 10.1021/jo048365f.

DOI:10.1021/jo048365f

PMID:15651792

Abstract

Total syntheses of (+)-cytisine, (-)-kuraramine, (-)-isokuraramine, and (-)-jussiaeiine A were achieved via a samarium diiodide-promoted reductive deamination reaction, followed by simultaneous recyclization of a proline derivative to give the corresponding delta-lactam derivative, as a key step.

摘要

通过二碘化钐促进的还原脱氨反应，随后使脯氨酸衍生物同时环化以得到相应的δ-内酰胺衍生物，实现了(+)-金雀花碱、(-)-苦参胺、(-)-异苦参胺和(-)-朱西厄碱A的全合成，这是关键步骤。