Jeong Hye Jin, Cho Sung Won, Kim Hyun Ah, Lee Sook Hwan, Cho Jung Hyun, Choi Dong Hee, Kwon Hwang, Cha Won Tae, Han Jee Eun, Cha Kwang Yul
Genome Research Center for Reproductive Medicine and Infertility of Korea Ministry of Health and Welfare, CHA General Hospital, College of Medicine, Pochon CHA University, 606-5 Yeoksam-dong, Kangnam-gu, Seoul 135-081, Korea.
Yonsei Med J. 2004 Jun 30;45(3):479-82. doi: 10.3349/ymj.2004.45.3.479.
Premature ovarian failure (POF) is menopause before the age of 40 years. The frequency of POF is about 1% of all women. Recently inhibin alpha gene (INHalpha) has been indicated as candidate in POF pathogenesis. Inhibin, a glycoprotein, is a gonadal hormone, which can inhibit the synthesis and secretion of pituitary follicle-stimulating hormone (FSH), which has an important role in the recruitment and development of ovarian follicles during the folliculogenesis. G769A variation of INHalpha, alanine, is highly conserved across species, and has an important role of its receptor binding. We screened a G769A transition in the INHalpha from the total population of the patients of 84 women with POF and 100 normal fertile women. We found no variation between the normal subjects and the POF patients. G769A variation of INHalpha is rare in Korea women with POF.
卵巢早衰（POF）是指40岁之前出现绝经。POF在所有女性中的发生率约为1%。最近，抑制素α基因（INHα）已被指出是POF发病机制中的候选基因。抑制素是一种糖蛋白，属于性腺激素，它能够抑制垂体促卵泡生成素（FSH）的合成与分泌，而FSH在卵泡发生过程中对卵巢卵泡的募集和发育起着重要作用。INHα的G769A变异，即丙氨酸变异，在物种间高度保守，且在其受体结合方面具有重要作用。我们在84例POF患者和100例正常育龄妇女的总体人群中筛查了INHα基因的G769A转变。我们发现正常受试者与POF患者之间没有差异。在韩国POF女性中，INHα的G769A变异很罕见。
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