抑素-α 基因多态性与韩国女性卵巢早衰的关系。

Relationship between inhibin-α gene polymorphisms and premature ovarian failure in Korean women.

机构信息

Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul, Korea.

出版信息

Menopause. 2011 Nov;18(11):1232-6. doi: 10.1097/gme.0b013e31821d6f7e.

DOI:10.1097/gme.0b013e31821d6f7e

PMID:21785376

Abstract

OBJECTIVE

The aim of this study was to determine the relationship between inhibin-α (INHα) gene polymorphisms and the prevalence of premature ovarian failure (POF) in Korean women.

METHODS

The INHα -124A/G, -16C/T, 679G/A, and 769G/A polymorphisms were analyzed in 52 women with POF and 55 normal healthy women using polymerase chain reaction-restriction enzyme fragment length polymorphism analysis.

RESULTS

The 679G/A and 769G/A polymorphisms were not observed. The frequencies of the C allele of the INHα -16C/T polymorphism and the G allele of the INHα -124A/G polymorphism were significantly lower in the women with POF than in the normal control women. The frequencies of the CG haplotype allele of these INHα -16C/T and -124A/G gene polymorphisms were also significantly lower in the women with POF than in the control women.

CONCLUSIONS

The INHα -16C/T and -124A/G polymorphisms are genetic factors associated with the prevalence of POF in Korean women.

摘要

目的

本研究旨在探讨抑制素-α（INHα）基因多态性与韩国女性卵巢早衰（POF）患病率之间的关系。

方法

采用聚合酶链反应-限制性内切酶片段长度多态性分析方法，对 52 例 POF 患者和 55 例正常健康女性的 INHα-124A/G、-16C/T、679G/A 和 769G/A 多态性进行分析。

结果

未观察到 INHα-679G/A 和 769G/A 多态性。POF 患者 INHα-16C/T 多态性的 C 等位基因和 INHα-124A/G 多态性的 G 等位基因频率明显低于正常对照组。这些 INHα-16C/T 和-124A/G 基因多态性的 CG 单倍型等位基因频率在 POF 患者中也明显低于对照组。